MBBS, PhD, FRANZCO
Senior Lecturer, The University of Queensland
Dr David Holcombe is a fellowship-trained ophthalmologist in Toowoomba, Queensland. He specialises in cataract surgery, macular degeneration, diabetic retinopathy, glaucoma and retinal diseases. He holds a PhD from The University of Queensland and is a Senior Lecturer in Ophthalmology.
Dr David Holcombe is a fellowship-trained ophthalmologist providing comprehensive eye care to patients across Toowoomba and the Darling Downs. He specialises in cataract surgery, macular degeneration, diabetic retinopathy, retinal vascular disease, glaucoma and general ophthalmology.
Dr Holcombe graduated from The University of Queensland with a Bachelor of Medicine and Bachelor of Surgery (MBBS) before undertaking specialist ophthalmology training at leading Australian hospitals, including the Royal Victorian Eye and Ear Hospital. He was awarded Fellowship of the Royal Australian and New Zealand College of Ophthalmologists (FRANZCO) and subsequently completed a Doctor of Philosophy (PhD) at The University of Queensland, where his research focused on retinal neuroprotection and glaucoma.
In addition to his clinical practice, Dr Holcombe is a Senior Lecturer at The University of Queensland and remains actively involved in medical education and ophthalmic research. He has authored numerous peer-reviewed publications and regularly contributes to the training of future doctors and eye specialists.
Dr Holcombe is committed to delivering personalised, evidence-based care and helping patients achieve the best possible visual outcomes through modern diagnostic techniques, medical treatments and advanced surgical procedures.
Professional Memberships
Medical Credentials
The calcineurin inhibitor, FK506, does not alter glutamate transport in the ischaemic retina
Holcombe DJ, Gole GA, Barnett NL. Exp Eye Res. 2010 Aug;91(2):315-9.
Sliding conjunctival flap with adjunctive fibrin glue for surgical revision of dysfunctional filtration blebs
Lee GA, Holcombe DJ. Eye (Lond). 2010 Jun;24(6):947-53.
Selective inner retinal dysfunction precedes ganglion cell loss in a glaucoma model
Holcombe DJ, Lengefeld N, Gole GA, Barnett NL. Br J Ophthalmol. 2008 May;92(5):683-8.
The effects of acute intraocular pressure elevation on retinal glutamate transport
Holcombe DJ, Lengefeld N, Gole GA, Barnett NL. Acta Ophthalmol. 2008 Jun;86(4):408-14.
Topical interferon alfa-2b for the treatment of recalcitrant ocular surface squamous neoplasia
Holcombe DJ, Lee GA. Am J Ophthalmol. 2006 Oct;142(4):568-71.
Holcombe DJ, Lee GA (2009) Revision of dysfunctional filtering blebs by conjunctival advancement with bleb preservation. Ophthalmology Journal Club, Queensland Eye Hospital, Brisbane.
Holcombe DJ, Lee GA (2008) Is topical interferon alfa-2b useful for the treatment of recalcitrant OSSN? Ophthalmology Journal Club, Queensland Eye Hospital, Brisbane.
Holcombe DJ, Gole GA, Barnett NL (2007) Development and characterization of a glaucoma model. The Australian Society for Medical Research, Queensland Postgraduate Medical Research Conference. ** Awarded prize for presentation
Holcombe DJ, Gole GA, Lengefeld N, Barnett NL (2006) Development and characterization of a glaucoma model. Australasian Ophthalmic and Vision Sciences Meeting, Canberra, Australia. ** Awarded conference prize for presentation
Holcombe DJ, Lengefeld N, Gole GA, Barnett NL (2006) Blinded by the light: development and characterization of a glaucoma model. University of Queensland School of Medicine Postgraduate Student Conference, Brisbane, Australia. ** Awarded prize for presentation
Holcombe DJ, Lee GA (2006) Topical interferon for the treatment of ocular surface squamous neoplasia. Royal Australian and New Zealand College of Ophthalmologists, Queensland Branch Meeting, Cairns, Australia.
Holcombe DJ, Gole GA, Barnett NL (2006) Glutamate, glia, GLAST, and glaucoma. The Vision, Touch and Hearing Research Centre Seminar Series, University of Queensland, Brisbane, Australia.
Holcombe DJ, Gole GA, Barnett NL (2005) The application of laser biophysics to the development of a glaucoma model. The Vision, Touch and Hearing Research Centre Seminar Series, University of Queensland, Brisbane, Australia.
Holcombe DJ, Lee GA (2004) Topical interferon alfa-2b for the treatment of ocular surface squamous neoplasia. Ophthalmology Grand Rounds, Princess Alexandra Hospital, Brisbane, Australia.
Holcombe DJ, Gole GA, Barnett NL (2004) Neuroprotection through modulation of glutamate transport. The Vision, Touch and Hearing Research Centre Seminar Series, University of Queensland, Brisbane, Australia.
Holcombe DJ, Barnett NL, Gole GA (2004) Towards neuroprotection of the retina. Ophthalmology Grand Rounds, Princess Alexandra Hospital, Brisbane, Australia.
Lee GA, Holcombe DJ (2009) Sliding conjunctival flap with adjunctive fibrin glue for surgical revision of dysfunctional filtration blebs. World Glaucoma Congress, Boston, USA.
Barnett NL, Holcombe DJ, Lengefeld N, Gole GA (2007) Selective inner retinal dysfunction precedes ganglion cell loss in a glaucoma model. Australasian Ophthalmic and Vision Sciences Meeting, Canberra, Australia.
Holcombe DJ, Lengefeld N, Gole GA, Barnett NL (2007) Selective inhibition of inner retinal function correlates with intraocular pressure in a model of glaucoma. The Association for Vision Research and Ophthalmology Conference (ARVO). Invest Ophthalmol Vis Sci 48: E-abstract 209.
Barnett NL, Holcombe DJ, Lengefeld N, Gole GA (2007) Retinal glutamate transport is related to intraocular pressure and cellular hypoxia. The Association for Vision Research and Ophthalmology Conference (ARVO). Invest Ophthalmol Vis Sci 48: E-abstract 4196.
Holcombe DJ, Gole GA, Lengefeld N, Barnett NL (2005) Retinal glutamate transport activity correlates with intraocular pressure. Australasian Ophthalmic and Vision Sciences Meeting, Melbourne, Australia. ** Awarded conference poster prize
Holcombe DJ, Gole GA, Grozdanic SD, Barnett NL (2005) Perturbed retinal glutamate transport in a model of chronic ocular hypertension. The Association for Vision Research and Ophthalmology Conference (ARVO). Invest Ophthalmol Vis Sci 46: E-abstract 3786.
Lee GA, Holcombe DJ (2005) Topical interferon alfa-2b in the treatment of recalcitrant ocular surface squamous neoplasia. World Cornea Congress, Washington DC, USA.
Barnett NL, Holcombe DJ, Gole GA, Grozdanic S (2005) Altered retinal glutamate transport in a laser-induced model of chronic ocular hypertension. Proceedings of the Australian Neuroscience Society 16: 159.
Holcombe DJ, Gole GA, Barnett NL (2004) Neuroprotection by FK506 is not mediated via glutamate transport modulation during retinal ischaemia. Vision Down Under, XVI International Congress of Eye Research Satellite Meeting, Fraser Island, Australia.