About
Dr David Holcombe
BSc MBBS PhD FRANZCO
Senior Lecturer University of Queensland
Dr David Holcombe graduated from the University of Queensland Medical School with a combined Bachelor of Medicine / Bachelor of Surgery, and a Doctor of Philosophy (MBBS PhD). The topic of his PhD was retinal neuro-protection. During the period of his PhD, Dr Holcombe tutored medical students at the University of Queensland.
Dr Holcombe did his residency years at the Royal Brisbane Hospital before being selected for the Royal Australian and New Zealand College of Ophthalmology training program in Melbourne where he spent considerable time training at the prestigious Royal Victorian Eye and Ear Hospital. He undertook two years of basic ophthalmology training, followed by two years of advanced training, and a further year of subspecialisation in the areas of cataract surgery and retinal disease, including macula degeneration and diabetic retinopathy.
Dr Holcombe then relocated back to South East Queensland to establish Toowoomba Ophthalmic Consultants at 20 Goggs Street Toowoomba, with the aim of providing the very best for his patients and their vision with excellence in knowledge, equipment, and facilities, and a caring friendly environment. He remains actively involved with teaching, regularly tutoring medical students, optometry students, and optometrists and holds the position of Senior Lecturer at the University of Queensland Medical School.
Teaching
Senior Lecturer 2015 - current
School of Medicine, University of QueenslandLecturer 2008 – 2009
School of Medicine, University of Queensland
Doctor of Philosophy
Dr Holcombe has completed a PhD at the University of Queensland (2007) entitled: Development and characterization of a glaucoma model and investigations into retinal glutamate transport. This PhD was supervised by Dr Nigel Barnett (DPhil) and Professor Glen Gole (MBBS MD FRANZCO FRACS). It was examined by Professor Neville N. Obsorne, University of Oxford UK, and Professor Jonathon Stone, University of Sydney. This PhD investigated the mechanisms of ganglion cell death in glaucoma using immunohistochemical, histochemical, and electroretinographical techniques.
The Professor of Ophthalmology at Oxford University final comments included, “My overall conclusion is that the candidate has produced an excellent thesis both in content and discussion……The candidate needs to be complimented for producing an excellent and outstanding thesis free of any major errors and significant in content. My recommendation, is that the thesis be accepted as outstanding and worthy for the award of a PhD degree”.
Holcombe DJ, Gole GA, Barnett NL. The calcineurin inhibitor, FK506, does not alter glutamate transport in the ischaemic retina. Exp Eye Res. 2010 Aug;91(2):315-9. Epub 2010 Apr 29.
Lee GA, Holcombe DJ. Sliding conjunctival flap with adjunctive fibrin glue for surgical revision of dysfunctional filtration blebs. Eye. (Lond). 2010 Jun;24(6):947-53. Epub 2009 Nov 27.
Holcombe DJ, Lengefeld N, Gole GA, Barnett NL. Selective inner retinal dysfunction precedes ganglion cell loss in a glaucoma model. Br J Ophthalmol. 2008 May;92(5):683-8. Epub 2008 Feb 22.
Holcombe DJ, Lengefeld N, Gole GA, Barnett NL. The effects of acute intraocular pressure elevation on retinal glutamate transport. Acta Ophthalmol. 2008 Jun;86(4):408-14. Epub 2007 Nov 19.
Holcombe DJ, Lee GA. Topical interferon alfa-2b for the treatment of recalcitrant ocular surface squamous neoplasia. Am J Ophthalmol. 2006 Oct;142(4):568-71.
Best student platform presentation: The Australian Society for Medical Research, Queensland Postgraduate Medical Research Conference (2007). Development and characterization of a glaucoma model.
Best student platform presentation: Australian Ophthalmic and Vision Sciences Meeting (2006). Development and characterization of a glaucoma model.
Award for platform presentation: University of Queensland School of Medicine Postgraduate Student Conference (2006). Blinded by the light: development and characterization of a glaucoma model.
Best student poster presentation: Australasian Ophthalmic and Vision Sciences Meeting (2005). Retinal glutamate transport activity correlates with intraocular pressure.
Holcombe DJ, Lee GA (2009) Revision of dysfunctional filtering blebs by conjunctival advancement with bleb preservation. Ophthalmology Journal Club, Queensland Eye Hospital, Brisbane.
Holcombe DJ, Lee GA (2008) Is topical interferon alfa-2b useful for the treatment of recalcitrant OSSN? Ophthalmology Journal Club, Queensland Eye Hospital, Brisbane.
Holcombe DJ, Gole GA, Barnett NL (2007) Development and characterization of a glaucoma model. The Australian Society for Medical Research, Queensland Postgraduate Medical Research Conference. ** Awarded prize for presentation
Holcombe DJ, Gole GA, Lengefeld N, Barnett NL (2006) Development and characterization of a glaucoma model. Australasian Ophthalmic and Vision Sciences Meeting, Canberra, Australia. ** Awarded conference prize for presentation
Holcombe DJ, Lengefeld N, Gole GA, Barnett NL (2006) Blinded by the light: development and characterization of a glaucoma model. University of Queensland School of Medicine Postgraduate Student Conference, Brisbane, Australia. ** Awarded prize for presentation
Holcombe DJ, Lee GA (2006) Topical interferon for the treatment of ocular surface squamous neoplasia. Royal Australian and New Zealand College of Ophthalmologists, Queensland Branch Meeting, Cairns, Australia.
Holcombe DJ, Gole GA, Barnett NL (2006) Glutamate, glia, GLAST, and glaucoma. The Vision, Touch and Hearing Research Centre Seminar Series, University of Queensland, Brisbane, Australia.
Holcombe DJ, Gole GA, Barnett NL (2005) The application of laser biophysics to the development of a glaucoma model. The Vision, Touch and Hearing Research Centre Seminar Series, University of Queensland, Brisbane, Australia.
Holcombe DJ, Lee GA (2004) Topical interferon alfa-2b for the treatment of ocular surface squamous neoplasia. Ophthalmology Grand Rounds, Princess Alexandra Hospital, Brisbane, Australia.
Holcombe DJ, Gole GA, Barnett NL (2004) Neuroprotection through modulation of glutamate transport. The Vision, Touch and Hearing Research Centre Seminar Series, University of Queensland, Brisbane, Australia.
Holcombe DJ, Barnett NL, Gole GA (2004) Towards neuroprotection of the retina. Ophthalmology Grand Rounds, Princess Alexandra Hospital, Brisbane, Australia.
Lee GA, Holcombe DJ (2009) Sliding conjunctival flap with adjunctive fibrin glue for surgical revision of dysfunctional filtration blebs. World Glaucoma Congress, Boston, USA.
Barnett NL, Holcombe DJ, Lengefeld N, Gole GA (2007) Selective inner retinal dysfunction precedes ganglion cell loss in a glaucoma model. Australasian Ophthalmic and Vision Sciences Meeting, Canberra, Australia.
Holcombe DJ, Lengefeld N, Gole GA, Barnett NL (2007) Selective inhibition of inner retinal function correlates with intraocular pressure in a model of glaucoma. The Association for Vision Research and Ophthalmology Conference (ARVO). Invest Ophthalmol Vis Sci 48: E-abstract 209.
Barnett NL, Holcombe DJ, Lengefeld N, Gole GA (2007) Retinal glutamate transport is related to intraocular pressure and cellular hypoxia. The Association for Vision Research and Ophthalmology Conference (ARVO). Invest Ophthalmol Vis Sci 48: E-abstract 4196.
Holcombe DJ, Gole GA, Lengefeld N, Barnett NL (2005) Retinal glutamate transport activity correlates with intraocular pressure. Australasian Ophthalmic and Vision Sciences Meeting, Melbourne, Australia. ** Awarded conference poster prize
Holcombe DJ, Gole GA, Grozdanic SD, Barnett NL (2005) Perturbed retinal glutamate transport in a model of chronic ocular hypertension. The Association for Vision Research and Ophthalmology Conference (ARVO). Invest Ophthalmol Vis Sci 46: E-abstract 3786.
Lee GA, Holcombe DJ (2005) Topical interferon alfa-2b in the treatment of recalcitrant ocular surface squamous neoplasia. World Cornea Congress, Washington DC, USA.
Barnett NL, Holcombe DJ, Gole GA, Grozdanic S (2005) Altered retinal glutamate transport in a laser-induced model of chronic ocular hypertension. Proceedings of the Australian Neuroscience Society 16: 159.
Barnett NL, Holcombe DJ, Gole GA, Grozdanic S (2005) Altered retinal glutamate transport in a laser-induced model of chronic ocular hypertension. Proceedings of the Australian Neuroscience Society 16: 159.
Holcombe DJ, Gole GA, Barnett NL (2004) Neuroprotection by FK506 is not mediated via glutamate transport modulation during retinal ischaemia. Vision Down Under, XVI International Congress of Eye Research Satellite Meeting, Fraser Island, Australia.
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